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Increased sensitivity of p53-deficient cells to anticancer agents due to loss of Pms2
A large fraction of human tumours carries mutations in the p53 gene. p53 plays a central role in controlling cell cycle checkpoint regulation, DNA repair, transcription, and apoptosis upon genotoxic stress. Lack of p53 function impairs these cellular processes, and this may be the basis of resistanc...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2002
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2364320/ https://ncbi.nlm.nih.gov/pubmed/12434296 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6600599 |
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