A phase I trial of antibody directed enzyme prodrug therapy (ADEPT) in patients with advanced colorectal carcinoma or other CEA producing tumours

Antibody-directed enzyme prodrug therapy is a targeted therapy in which a prodrug is activated selectively at the tumour site by an enzyme, which has been targeted to the tumour by an antibody (antibody-enzyme conjugate). Previous clinical trials have shown evidence of tumour response, however, the...

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Detalhes bibliográficos
Main Authors: Francis, R J, Sharma, S K, Springer, C, Green, A J, Hope-Stone, L D, Sena, L, Martin, J, Adamson, K L, Robbins, A, Gumbrell, L, O'Malley, D, Tsiompanou, E, Shahbakhti, H, Webley, S, Hochhauser, D, Hilson, A J, Blakey, D, Begent, R H J
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2002
Assuntos:
Clinical
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2364249/
https://ncbi.nlm.nih.gov/pubmed/12237768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6600517
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