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Mechanisms of nordihydroguaiaretic acid-induced growth inhibition and apoptosis in human cancer cells

Lipoxygenase metabolites of arachidonic acid can act as growth promoting factors for various cancer cell lines. Here we demonstrate that the 5-lipoxygenase inhibitor nordihydroguaiaretic acid potently inhibits anchorage-independent growth of human pancreatic and cervical cancer cells in soft agar an...

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Autors principals: Seufferlein, T, Seckl, M J, Schwarz, E, Beil, M, v Wichert, G, Baust, H, Lührs, H, Schmid, R M, Adler, G
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2002
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2364182/
https://ncbi.nlm.nih.gov/pubmed/11953870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6600186
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