Reduced 5-FU clearance in a patient with low DPD activity due to heterozygosity for a mutant allele of the DPYD gene

5-fluorouracil pharmacokinetics, dihydropyrimidine dehydrogenase-activity and DNA sequence analysis were compared between a patient with extreme 5-fluorouracil induced toxicity and six control patients with normal 5-fluorouracil related symptoms. Patients were treated for colorectal cancer and recei...

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Detalhes bibliográficos
Main Authors: Maring, J G, van Kuilenburg, A B P, Haasjes, J, Piersma, H, Groen, H J M, Uges, D R A, Van Gennip, A H, De Vries, E G E
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2002
Assuntos:
Clinical
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2364178/
https://ncbi.nlm.nih.gov/pubmed/11953843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6600208
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