Human immunodeficiency virus type 1 integrase: effect on viral replication of mutations at highly conserved residues.

Sequence comparisons of the integrase (IN) proteins from different retroviruses have identified several highly conserved residues. We have introduced mutations at 16 of these sites into the integrase gene of human immunodeficiency virus type 1 and analyzed the phenotypes of the resulting viruses. Th...

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Veröffentlicht in:	J Virol
Hauptverfasser:	Cannon, P M, Wilson, W, Byles, E, Kingsman, S M, Kingsman, A J
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 1994
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC236416/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8035478/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.68.8.4768-4775.1994
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