Human immunodeficiency virus type 1 integrase: effect on viral replication of mutations at highly conserved residues.

Sequence comparisons of the integrase (IN) proteins from different retroviruses have identified several highly conserved residues. We have introduced mutations at 16 of these sites into the integrase gene of human immunodeficiency virus type 1 and analyzed the phenotypes of the resulting viruses. Th...

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Dades bibliogràfiques

Publicat a:	J Virol
Autors principals:	Cannon, P M, Wilson, W, Byles, E, Kingsman, S M, Kingsman, A J
Format:	Artigo
Idioma:	Inglês
Publicat:	American Society for Microbiology (ASM) 1994
Matèries:	Research Article
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC236416/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8035478/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.68.8.4768-4775.1994
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