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Mutation analysis of the CHK2 gene in families with hereditary breast cancer
Recently CHK2 was functionally linked to the p53 pathway, and mutations in these two genes seem to result in a similar Li–Fraumeni syndrome (LFS) or Li–Fraumeni-like syndrome (LFL) multi-cancer phenotype frequently including breast cancer. As CHK2 has been found to bind and regulate BRCA1, the produ...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2001
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2364033/ https://ncbi.nlm.nih.gov/pubmed/11461078 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1054/bjoc.2001.1858 |
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