Germline TP53 alterations in Finnish breast cancer families are rare and occur at conserved mutation-prone sites

We have screened for germline TP53 mutations in Finnish BRCA1 and BRCA2 mutation-negative families. This study represents the largest survey of the entire protein-encoding portion of TP53, and indicates that mutations are only found at conserved domains in breast cancer families also meeting the cri...

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Detalhes bibliográficos
Main Authors: Rapakko, K, Allinen, M, Syrjäkoski, K, Vahteristo, P, Huusko, P, Vähäkangas, K, Eerola, H, Kainu, T, Kallioniemi, O-P, Nevanlinna, H, Winqvist, R
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2001
Assuntos:
Short Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2363618/
https://ncbi.nlm.nih.gov/pubmed/11139324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1054/bjoc.2000.1530
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