High levels of the MDM2 oncogene in paediatric rhabdomyosarcoma cell lines may confer multidrug resistance

The MDM2 protein is known to be overexpressed in some sarcomas including rhabdomyosarcoma. However, the extent to which the MDM2 protein influences sensitivity to chemotherapeutic drugs is unclear. We have analysed this further using stable transfection of the mdm2 gene into 4 well-characterised hum...

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Библиографические подробности
Главные авторы: Cocker, H A, Hobbs, S M, Tiffin, N, Pritchard-Jones, K, Pinkerton, C R, Kelland, L R
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group 2001
Предметы:
Regular Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2363993/
https://ncbi.nlm.nih.gov/pubmed/11742497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1054/bjoc.2001.2145
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