Frequent k- ras -2 mutations and p16(INK4A)methylation in hepatocellular carcinomas in workers exposed to vinyl chloride

Vinyl chloride (VC) is a know animal and human carcinogen associated with liver angiosarcomas (LAS) and hepatocellular carcinomas (HCC). In VC-associated LAS mutations of the K- ras -2 gene have been reported; however, no data about the prevalence of such mutations in VC associated HCCs are availabl...

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Bibliografiske detaljer
Main Authors: Weihrauch, M, Benicke, M, Lehnert, G, Wittekind, C, Wrbitzky, R, Tannapfel, A
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2001
Fag:
Regular Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2363841/
https://ncbi.nlm.nih.gov/pubmed/11286481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1054/bjoc.2000.1675
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