5-fluorouracil steady state pharmacokinetics and outcome in patients receiving protracted venous infusion for advanced colorectal cancer

PVI 5FU gives increased response rates and reduced toxicity when compared to bolus 5FU (J Clin Oncol 1989, 425–432). PVI 5FU administration was reported to give highly variable (>1000-fold) plasma 5FU concentrations at steady state (FU Css) which correlated with toxicity (Ann Oncol 1996, 47–53);...

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Hlavní autoři: Jodrell, D I, Stewart, M, Aird, R, Knowles, G, Bowman, A, Wall, L, Cummings, J, McLean, C
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2001
Témata:
Regular Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2363784/
https://ncbi.nlm.nih.gov/pubmed/11237378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1054/bjoc.2000.1664
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