Modulation of docetaxel-induced apoptosis and cell cycle arrest by all- trans retinoic acid in prostate cancer cells

We report that all- trans retinoic acid (ATRA) enhanced the toxicity of docetaxel against DU145 and LNCaP prostate cancer cells, and that the nature of the interaction between ATRA and docetaxel was highly synergistic. Docetaxel-induced apoptotic cell death was associated with phosphorylation and he...

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Detalhes bibliográficos
Main Authors: Nehmé, A, Varadarajan, P, Sellakumar, G, Gerhold, M, Niedner, H, Zhang, Q, Lin, X, Christen, R D
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2001
Assuntos:
Regular Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2363662/
https://ncbi.nlm.nih.gov/pubmed/11384110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1054/bjoc.2001.1818
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