Mutations in v-Src SH3 and catalytic domains that jointly confer temperature-sensitive transformation with minimal temperature-dependent changes in cellular tyrosine phosphorylation.

We have analyzed two functionally significant amino acid alterations encoded by the temperature-sensitive (ts) v-src mutant of Rous sarcoma virus, LA32. The G-to-V change at residue 300 in the catalytic domain nonconditionally impairs morphological transformation, in vitro kinase activity, in vivo t...

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Bibliografiske detaljer

Udgivet i:	J Virol
Principais autores:	Catling, A D, Fincham, V J, Frame, M C, Haefner, B, Wyke, J A
Format:	Artigo
Sprog:	Inglês
Udgivet:	American Society for Microbiology (ASM) 1994
Fag:	Research Article
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC236363/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8207813/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.68.7.4392-4399.1994
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