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Mutations in v-Src SH3 and catalytic domains that jointly confer temperature-sensitive transformation with minimal temperature-dependent changes in cellular tyrosine phosphorylation.

We have analyzed two functionally significant amino acid alterations encoded by the temperature-sensitive (ts) v-src mutant of Rous sarcoma virus, LA32. The G-to-V change at residue 300 in the catalytic domain nonconditionally impairs morphological transformation, in vitro kinase activity, in vivo t...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Catling, A D, Fincham, V J, Frame, M C, Haefner, B, Wyke, J A
Format: Artigo
Sprache:Inglês
Veröffentlicht: 1994
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC236363/
https://ncbi.nlm.nih.gov/pubmed/8207813
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