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A randomized trial of 13-Cis retinoic acid in children with advanced neuroblastoma after high-dose therapy

One hundred and seventy-five children with Stage 3 or 4 neuroblastoma who had obtained a good response to conventional therapy were randomly allocated to 13-Cis retinoic acid at a dose of 0.75 mg/kg/day or placebo for up to 4 years. Toxicity was mild but no advantage in event-free survival was shown...

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Autors principals: Kohler, J A, Imeson, J, Ellershaw, C, Lie, S O
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2000
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2363577/
https://ncbi.nlm.nih.gov/pubmed/11027423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1054/bjoc.2000.1425
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