Inhibition of angiogenesis and tumour growth by VEGF121–toxin conjugate: differential effect on proliferating endothelial cells

Vascular endothelial growth factor (VEGF) plays an important role in tumour angiogenesis. VEGF binds to tyrosine kinase receptors, which are expressed almost exclusively on tumour endothelium. Therefore, VEGF can be used to target toxin molecules to tumour vessels for anti-angiogenic therapy. Howeve...

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Detalhes bibliográficos
Main Authors: Wild, R, Dhanabal, M, Olson, T A, Ramakrishnan, S
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2000
Assuntos:
Regular Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2363558/
https://ncbi.nlm.nih.gov/pubmed/10993657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1054/bjoc.2000.1439
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