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Loss of Fhit expression in non-small-cell lung cancer: correlation with molecular genetic abnormalities and clinicopathological features

The FHIT gene is located at a chromosomal site (3p14.2) which is commonly affected by translocations and deletions in human neoplasia. Although FHIT alterations at the DNA and RNA level are frequent in many types of tumours, the biological and clinical significance of these changes is not clear. In...

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Autori principali: Geradts, J, Fong, K M, Zimmerman, P V, Minna, J D
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2000
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2363352/
https://ncbi.nlm.nih.gov/pubmed/10735505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1054/bjoc.1999.1062
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