NADPH:cytochrome c (P450) reductase activates tirapazamine (SR4233) to restore hypoxic and oxic cytotoxicity in an aerobic resistant derivative of the A549 lung cancer cell line

Tirapazamine (TPZ, SR4233, WIN 59075) is a bioreductive drug that is activated in regions of low oxygen tension to a cytotoxic radical intermediate. This labile metabolite shows high selective toxicity towards hypoxic cells, such as those found in solid tumours. Under aerobic conditions, redox cycli...

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Bibliographic Details
Main Authors: Saunders, M P, Patterson, A V, Chinje, E C, Harris, A L, Stratford, I J
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2000
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Regular Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2363339/
https://ncbi.nlm.nih.gov/pubmed/10682679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1054/bjoc.1999.0977
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