Importance of P450 reductase activity in determining sensitivity of breast tumour cells to the bioreductive drug, tirapazamine (SR 4233).

P450 reductase (NADPH:cytochrome P450 reductase, EC 1.6.2.4) is known to be important in the reductive activation of the benzotriazene-di-N-oxide tirapazamine (SR 4233). Using a panel of six human breast adenocarcinoma cell lines we have examined the relationship between P450 reductase activity and...

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Main Authors: Patterson, A. V., Barham, H. M., Chinje, E. C., Adams, G. E., Harris, A. L., Stratford, I. J.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Publishing Group 1995
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2033939/
https://ncbi.nlm.nih.gov/pubmed/7577460
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