Enhancement of chemotherapy and radiotherapy of murine tumours by AQ4N, a bioreductively activated anti-tumour agent

AQ4 (1,4-Bis-{[2-(dimethylamino-N-oxide)ethyl]amino}5,8-dihydroxyanthracene-9, 10-dione) is a prodrug designed to be excluded from cell nuclei until bioreduced in hypoxic cells to AQ4, a DNA intercalator and topoisomerase II poison. Thus, AQ4N is a highly selective bioreductive drug that is activate...

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Bibliografiske detaljer
Main Authors: Patterson, L H, McKeown, S R, Ruparelia, K, Double, J A, Bibby, M C, Cole, S, Stratford, I J
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2000
Fag:
Regular Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2363261/
https://ncbi.nlm.nih.gov/pubmed/10864207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1054/bjoc.2000.1163
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