Enhancement of chemotherapy and radiotherapy of murine tumours by AQ4N, a bioreductively activated anti-tumour agent

AQ4 (1,4-Bis-{[2-(dimethylamino-N-oxide)ethyl]amino}5,8-dihydroxyanthracene-9, 10-dione) is a prodrug designed to be excluded from cell nuclei until bioreduced in hypoxic cells to AQ4, a DNA intercalator and topoisomerase II poison. Thus, AQ4N is a highly selective bioreductive drug that is activate...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Patterson, L H, McKeown, S R, Ruparelia, K, Double, J A, Bibby, M C, Cole, S, Stratford, I J
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2000
Assuntos:
Regular Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2363261/
https://ncbi.nlm.nih.gov/pubmed/10864207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1054/bjoc.2000.1163
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados