Phase II study of the oxygen saturation curve left shifting agent BW12C in combination with the hypoxia activated drug mitomycin C in advanced colorectal cancer

BW12C (5-[2-formyl-3-hydroxypenoxyl] pentanoic acid) stabilizes oxyhaemoglobin, causing a reversible left-shift of the oxygen saturation curve (OSC) and tissue hypoxia. The activity of mitomycin C (MMC) is enhanced by hypoxia. In this phase II study, 17 patients with metastatic colorectal cancer res...

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Detalhes bibliográficos
Main Authors: Propper, D J, Levitt, N C, O'Byrne, K, Braybrooke, J P, Talbot, D C, Ganesan, T S, Thompson, C H, Rajagopalan, B, Littlewood, T J, Dixon, R M, Harris, A L
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2000
Assuntos:
Regular Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2363221/
https://ncbi.nlm.nih.gov/pubmed/10839290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1054/bjoc.2000.1138
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