Phase I study of the mitomycin C analogue BMS-181174.

BMS-181174 is an aminodisulphide derivative of Mitomycin C (MMC) with activity against a range of tumour cell lines and xenografts, including MMC-resistant tumours. In a phase I study of 82 patients with confirmed malignancy, we administered BMS-181174 at doses of 0.8-75 mg m(-2) by intravenous inje...

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Autori principali: Macaulay, V. M., O'Byrne, K. J., Green, J. A., Philip, P. A., McKinley, L., LaCreta, F. P., Winograd, B., Ganesan, T. S., Harris, A. L., Talbot, D. C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 1998
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2150373/
https://ncbi.nlm.nih.gov/pubmed/9667686
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