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Mathematical and experimental analysis of localization of anti-tumour antibody–enzyme conjugates

Considerable research has been aimed at improving the efficacy of chemotherapeutic agents for cancer therapy. A promising two-step approach that is designed to minimize systemic drug toxicity while maximizing activity in tumours employs monoclonal antibody (mAb)–enzyme conjugates for the activation...

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Autors principals: Jackson, T L, Lubkin, S R, Siemers, N O, Kerr, D E, Senter, P D, Murray, J D
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 1999
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2363130/
https://ncbi.nlm.nih.gov/pubmed/10468291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6690592
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