Enhancement of chemotherapy by manipulation of tumour pH

The extracellular (interstitial) pH (pHe) of solid tumours is significantly more acidic compared to normal tissues. In-vitro, low pH reduces the uptake of weakly basic chemotherapeutic drugs and, hence, reduces their cytotoxicity. This phenomenon has been postulated to contribute to a ‘physiological...

Descripció completa

Guardat en:
Dades bibliogràfiques
Autors principals: Raghunand, N, He, X, Sluis, R van, Mahoney, B, Baggett, B, Taylor, C W, Paine-Murrieta, G, Roe, D, Bhujwalla, Z M, Gillies, R J
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 1999
Matèries:
Regular Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2363059/
https://ncbi.nlm.nih.gov/pubmed/10362108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6690455
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars