Enhancement of chemotherapy by manipulation of tumour pH

The extracellular (interstitial) pH (pHe) of solid tumours is significantly more acidic compared to normal tissues. In-vitro, low pH reduces the uptake of weakly basic chemotherapeutic drugs and, hence, reduces their cytotoxicity. This phenomenon has been postulated to contribute to a ‘physiological...

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Dettagli Bibliografici
Autori principali: Raghunand, N, He, X, Sluis, R van, Mahoney, B, Baggett, B, Taylor, C W, Paine-Murrieta, G, Roe, D, Bhujwalla, Z M, Gillies, R J
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 1999
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Regular Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2363059/
https://ncbi.nlm.nih.gov/pubmed/10362108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6690455
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