The acridonecarboxamide GF120918 potently reverses P-glycoprotein-mediated resistance in human sarcoma MES-Dx5 cells

The doxorubicin-selected, P-glycoprotein (P-gp)-expressing human sarcoma cell line MES-Dx5 showed the following levels of resistance relative to the non-P-gp-expressing parental MES-SA cells in a 72 h exposure to cytotoxic drugs: etoposide twofold, doxorubicin ninefold, vinblastine tenfold, taxotere...

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Bibliographic Details
Main Authors: Traunecker, H C L, Stevens, M C G, Kerr, D J, Ferry, D R
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 1999
Subjects:
Regular Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2362940/
https://ncbi.nlm.nih.gov/pubmed/10576649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6690791
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