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Cellular uptake, cytotoxicity and DNA-binding studies of the novel imidazoacridinone antineoplastic agent C1311

C1311 is a novel therapeutic agent with potent activity against experimental colorectal cancer that has been selected for entry into clinical trial. The compound has previously been shown to have DNA-binding properties and to inhibit the catalytic activity of topoisomerase II. In this study, cellula...

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Bibliografski detalji
Glavni autori: Burger, A M, Jenkins, T C, Double, J A, Bibby, M C
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 1999
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2362878/
https://ncbi.nlm.nih.gov/pubmed/10496367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6690702
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