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Cell killing by the novel imidazoacridinone antineoplastic agent, C-1311, is inhibited at high concentrations coincident with dose-differentiated cell cycle perturbation.

We have studied the actions of C-1311, an imidazoacridinone analogue with potent in vivo antitumour activity, against a human tumour line (HeLa S3), in an examination of the events associated with the lethality of this agent. Continuous exposures (24 h) induced complete G2 arrest, although the conce...

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Detalhes bibliográficos
Main Authors: Lamb, J., Wheatley, D. N.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 1996
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2074775/
https://ncbi.nlm.nih.gov/pubmed/8912530
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