In vivo efficacy of XR9051, a potent modulator of P-glycoprotein mediated multidrug resistance

Overexpression of P-glycoprotein (P-gp) is a potential cause of multidrug resistance (MDR) in tumours. We have previously reported that XR9051 (N-(4-(2-(6,7-dimethoxy-1,2,3,4-tetrahydro-2-isoquinolyl)ethyl)phenyl)-3-((3Z,6Z)-6-benzylidene-1-methyl-2,5-dioxo-3-piperazinylidene)methylbenzamide) is a p...

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Detalhes bibliográficos
Main Authors: Mistry, P, Plumb, J, Eccles, S, Watson, S, Dale, I, Ryder, H, Box, G, Charlton, P, Templeton, D, Bevan, P B
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 1999
Assuntos:
Regular Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2362811/
https://ncbi.nlm.nih.gov/pubmed/10206276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6690267
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