Identification of a C/G polymorphism in the promoter region of the BRCA1 gene and its use as a marker for rapid detection of promoter deletions

Reduced expression of BRCA1 has been implicated in sporadic breast cancer, although the mechanisms underlying this phenomenon remain unclear. To determine whether regulatory mutations could account for the reduced expression, we screened the promoter region by sequencing in 20 patients with sporadic...

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Detalhes bibliográficos
Main Authors: Catteau, A, Xu, C-F, Brown, M A, Hodgson, S, Greenman, J, Mathew, C G, Dunning, A M, Solomon, E
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 1999
Assuntos:
Regular Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2362680/
https://ncbi.nlm.nih.gov/pubmed/10070866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6690122
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