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G1 checkpoint protein and p53 abnormalities occur in most invasive transitional cell carcinomas of the urinary bladder
The G1 cell cycle checkpoint regulates entry into S phase for normal cells. Components of the G1 checkpoint, including retinoblastoma (Rb) protein, cyclin D1 and p16(INK4a), are commonly altered in human malignancies, abrogating cell cycle control. Using immunohistochemistry, we examined 79 invasive...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
1999
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2362363/ https://ncbi.nlm.nih.gov/pubmed/10376969 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6990483 |
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