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Expression of collagenases-1 and -3 and their inhibitors TIMP-1 and -3 correlates with the level of invasion in malignant melanomas

Since proteolysis of the dermal collagenous matrix and basement membranes is required for local invasive growth and early metastasis formation of cutaneous melanomas, we have analysed the activities/expression levels of certain metalloproteinases in melanomas and cultured melanoma cells by in situ h...

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Autori principali: Airola, K, Karonen, T, Vaalamo, M, Lehti, K, Lohi, J, Kariniemi, A-L, Keski-Oja, J, Saarialho-Kere, U K
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 1999
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2362286/
https://ncbi.nlm.nih.gov/pubmed/10360651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6690417
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