Loss of DNA mismatch repair facilitates reactivation of a reporter plasmid damaged by cisplatin

In addition to recognizing and repairing mismatched bases in DNA, the mismatch repair (MMR) system also detects cisplatin DNA adducts and loss of MMR results in resistance to cisplatin. A comparison was made of the ability of MMR-proficient and -deficient cells to remove cisplatin adducts from their...

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Bibliographic Details
Main Authors: Cenni, B, Kim, H-K, Bubley, G J, Aebi, S, Fink, D, Teicher, B A, Howell, S B, Christen, R D
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 1999
Subjects:
Regular Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2362265/
https://ncbi.nlm.nih.gov/pubmed/10360646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6690412
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