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Loss of DNA mismatch repair facilitates reactivation of a reporter plasmid damaged by cisplatin
In addition to recognizing and repairing mismatched bases in DNA, the mismatch repair (MMR) system also detects cisplatin DNA adducts and loss of MMR results in resistance to cisplatin. A comparison was made of the ability of MMR-proficient and -deficient cells to remove cisplatin adducts from their...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
1999
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2362265/ https://ncbi.nlm.nih.gov/pubmed/10360646 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6690412 |
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