Aspirin-induced nuclear translocation of NFκB and apoptosis in colorectal cancer is independent of p53 status and DNA mismatch repair proficiency

Substantial evidence indicates nonsteroidal anti-inflammatory drugs (NSAIDs) protect against colorectal cancer (CRC). However, the molecular basis for this anti-tumour activity has not been fully elucidated. We previously reported that aspirin induces signal-specific IκBα degradation followed by NFκ...

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Bibliographic Details
Main Authors: Din, F V N, Stark, L A, Dunlop, M G
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2005
Subjects:
Genetics and Genomics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2361954/
https://ncbi.nlm.nih.gov/pubmed/15770215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6602455
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