Aberrant methylation of SPARC in human lung cancers

SPARC (secreted protein acidic and rich in cysteine) is an extracellular Ca(2+)-binding matricellular glycoprotein associated with the regulation of cell adhesion and growth. We investigated loss of expression of SPARC gene and promoter methylation in lung cancers and correlated the data with clinic...

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Main Authors: Suzuki, M, Hao, C, Takahashi, T, Shigematsu, H, Shivapurkar, N, Sathyanarayana, U G, Iizasa, T, Fujisawa, T, Hiroshima, K, Gazdar, A F
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2005
Teme:
Molecular Diagnostics
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2361924/
https://ncbi.nlm.nih.gov/pubmed/15756262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6602376
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