Increasing the intracellular availability of all-trans retinoic acid in neuroblastoma cells

Recent data indicate that isomerisation to all-trans retinoic acid (ATRA) is the key mechanism underlying the favourable clinical properties of 13-cis retinoic acid (13cisRA) in the treatment of neuroblastoma. Retinoic acid (RA) metabolism is thought to contribute to resistance, and strategies to mo...

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Autori principali: Armstrong, J L, Ruiz, M, Boddy, A V, Redfern, C P F, Pearson, A D J, Veal, G J
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2005
Soggetti:
Translational Therapeutics
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2361877/
https://ncbi.nlm.nih.gov/pubmed/15714209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6602398
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