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The human papillomavirus E6 and E7 inducible oncogene, hWAPL, exhibits potential as a therapeutic target
Here we show that human papillomavirus (HPV) E6 and E7 oncoproteins induce hWAPL expression. In addition, small interfering RNA (siRNA) of hWAPL suppressed the growth of tumours derived from SiHa cells in nude mice. Thus, hWAPL may be one of the effective targets of uterine cervical cancer therapy.
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| Autors principals: | , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Nature Publishing Group
2005
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2361835/ https://ncbi.nlm.nih.gov/pubmed/15655544 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6602329 |
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