HOXB13 is downregulated in colorectal cancer to confer TCF4-mediated transactivation

Mutations in the Wnt signalling cascade are believed to cause aberrant proliferation of colorectal cells through T-cell factor-4 (TCF4) and its downstream growth-modulating factors. HOXB13 is exclusively expressed in prostate and colorectum. In prostate cancers, HOXB13 negatively regulates β-catenin...

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Dettagli Bibliografici
Autori principali: Jung, C, Kim, R-S, Zhang, H, Lee, S-J, Sheng, H, Loehrer, P J, Gardner, T A, Jeng, M-H, Kao, C
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2005
Soggetti:
Molecular Diagnostics
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2361828/
https://ncbi.nlm.nih.gov/pubmed/15928669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6602631
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