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HOXB13 is downregulated in colorectal cancer to confer TCF4-mediated transactivation
Mutations in the Wnt signalling cascade are believed to cause aberrant proliferation of colorectal cells through T-cell factor-4 (TCF4) and its downstream growth-modulating factors. HOXB13 is exclusively expressed in prostate and colorectum. In prostate cancers, HOXB13 negatively regulates β-catenin...
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| Hauptverfasser: | , , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Nature Publishing Group
2005
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2361828/ https://ncbi.nlm.nih.gov/pubmed/15928669 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6602631 |
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