Elimination of wild-type P53 mRNA in glioblastomas showing heterozygous mutations of P53

We screened 50 glioblastomas for P53 mutations. Five glioblastomas showed heterozygous mutations, while three were putatively heterozygous. Six of these eight glioblastomas showed elimination of wild-type P53 mRNA. These results strongly suggest that some sort of mechanism(s) favouring mutated over...

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Detalhes bibliográficos
Main Authors: Szybka, M, Zawlik, I, Kulczycka, D, Golanska, E, Jesien, E, Kupnicka, D, Stawski, R, Piaskowski, S, Bieniek, E, Zakrzewska, M, Kordek, R, Liberski, P P, Rieske, P
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2008
Assuntos:
Genetics and Genomics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2361718/
https://ncbi.nlm.nih.gov/pubmed/18349850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6604258
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