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Elimination of wild-type P53 mRNA in glioblastomas showing heterozygous mutations of P53
We screened 50 glioblastomas for P53 mutations. Five glioblastomas showed heterozygous mutations, while three were putatively heterozygous. Six of these eight glioblastomas showed elimination of wild-type P53 mRNA. These results strongly suggest that some sort of mechanism(s) favouring mutated over...
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| Main Authors: | , , , , , , , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Nature Publishing Group
2008
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2361718/ https://ncbi.nlm.nih.gov/pubmed/18349850 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6604258 |
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