Elimination of wild-type P53 mRNA in glioblastomas showing heterozygous mutations of P53

We screened 50 glioblastomas for P53 mutations. Five glioblastomas showed heterozygous mutations, while three were putatively heterozygous. Six of these eight glioblastomas showed elimination of wild-type P53 mRNA. These results strongly suggest that some sort of mechanism(s) favouring mutated over...

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Hlavní autoři: Szybka, M, Zawlik, I, Kulczycka, D, Golanska, E, Jesien, E, Kupnicka, D, Stawski, R, Piaskowski, S, Bieniek, E, Zakrzewska, M, Kordek, R, Liberski, P P, Rieske, P
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2008
Témata:
Genetics and Genomics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2361718/
https://ncbi.nlm.nih.gov/pubmed/18349850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6604258
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