Promoter hypermethylation of FANCF and outcome in advanced ovarian cancer

The Fanconi gene family has a role in DNA repair and inactivation of FANCF has been proposed as a mechanism of sensitisation to platinum chemotherapy. This study sought to confirm this hypothesis in cell lines and a large series of ovarian cancer samples. Promoter methylation was assessed by methyla...

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Bibliographische Detailangaben
Hauptverfasser: Lim, S L, Smith, P, Syed, N, Coens, C, Wong, H, van der Burg, M, Szlosarek, P, Crook, T, Green, J A
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2008
Schlagworte:
Genetics and Genomics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2361708/
https://ncbi.nlm.nih.gov/pubmed/18414472
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6604325
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