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hTERT phosphorylation by PKC is essential for telomerase holoprotein integrity and enzyme activity in head neck cancer cells

Telomerase activity is suppressed in normal somatic tissues but is activated in most cancer cells. We have previously found that all six telomerase subunit proteins, including hTERT and hsp90 are needed for full enzyme activity. Telomerase activity has been reported to be upregulated by protein kina...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Chang, J T, Lu, Y-C, Chen, Y-J, Tseng, C-P, Chen, Y-L, Fang, C-W, Cheng, A-J
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group 2006
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2361368/
https://ncbi.nlm.nih.gov/pubmed/16508638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6603008
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