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Simple and sensitive procedure for screening yeast mutants that lyse at nonpermissive temperatures.

After mutagenesis, surviving yeast cells are grown on plates at 25 C and later exposed to 37 C. The plates are then overlaid with a soft agar containing p-nitrophenylphosphate at pH 9.7. Lysed cells liberate alkaline phosphatase which gives rise to a yellow color on and around colonies.

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Bibliografiske detaljer
Main Authors: Cabib, E, Duran, A
Format: Artigo
Sprog:Inglês
Udgivet: 1975
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC236077/
https://ncbi.nlm.nih.gov/pubmed/372
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