Very low prevalence of germline MSH6 mutations in hereditary non-polyposis colorectal cancer suspected patients with colorectal cancer without microsatellite instability

Hereditary non-polyposis colorectal cancer (HNPCC) is caused by mutations in one of the mismatch repair genes MLH1, MSH2, MSH6, or PMS2 and results in high-level microsatellite instability (MSI-high) in tumours of HNPCC patients. The MSI test is considered reliable for indicating mutations in MLH1 a...

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Hlavní autoři: Kets, C M, van Krieken, J H J M, Hebeda, K M, Wezenberg, S J, Goossens, M, Brunner, H G, Ligtenberg, M J L, Hoogerbrugge, N
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2006
Témata:
Molecular Diagnostics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2360757/
https://ncbi.nlm.nih.gov/pubmed/17117178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6603478
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