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Mononucleotide microsatellite instability and germline MSH6 mutation analysis in early onset colorectal cancer

Germline mutations in the MSH2 and MLH1 mismatch repair genes account for most cases of hereditary non-polyposis colon cancer syndrome (HNPCC). In addition, germline MSH2 and MLH1 mutations have been detected in patients with non-HNPCC early onset colorectal cancer. Germline MSH6 mutations appear to...

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Hlavní autoři: Verma, L., Kane, M., Brassett, C., Schmeits, J., Evans, D, Kolodner, R., Maher, E.
Médium: Artigo
Jazyk:Inglês
Vydáno: BMJ Group 1999
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1734424/
https://ncbi.nlm.nih.gov/pubmed/10507723
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