11q13 amplification status and human papillomavirus in relation to p16 expression defines two distinct etiologies of head and neck tumours

Two distinct etiologies of head and neck squamous cell carcinoma (HNSCC) have been proposed, DNA damage owing to tobacco and alcohol exposure and human papillomavirus (HPV) oncogene-mediated transformation. Common genetic alterations in HNSCC include TP53 mutations, 11q13 amplification (amp) and CDK...

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Detalhes bibliográficos
Main Authors: Ragin, C C R, Taioli, E, Weissfeld, J L, White, J S, Rossie, K M, Modugno, F, Gollin, S M
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2006
Assuntos:
Genetics and Genomics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2360598/
https://ncbi.nlm.nih.gov/pubmed/17003776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6603394
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