Fludarabine-mediated suppression of the excision repair enzyme ERCC1 contributes to the cytotoxic synergy with the DNA minor groove crosslinking agent SJG-136 (NSC 694501) in chronic lymphocytic leukaemia cells

In this study, we set out to establish whether fludarabine could enhance the DNA interstrand crosslinking capacity of SJG-136 in primary human chronic lymphocytic leukaemia (CLL) cells and thereby offer a rationale for its clinical use in combination with SJG-136. SJG-136 rapidly induced DNA crossli...

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Bibliographische Detailangaben
Hauptverfasser: Pepper, C, Lowe, H, Fegan, C, Thurieau, C, Thurston, D E, Hartley, J A, Delavault, P
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2007
Schlagworte:
Genetics and Genomics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2360304/
https://ncbi.nlm.nih.gov/pubmed/17579621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6603853
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