Combination therapy with PEG-IFN-α and 5-FU inhibits HepG2 tumour cell growth in nude mice by apoptosis of p53

When the tumour suppressor p53 is activated by DNA damage, it stimulates the transcription of its target genes, which then induce cell cycle arrest or apoptosis. Here, we examined the role p53 plays in the antitumour effect of combination treatment with pegylated interferon (PEG-IFN)-α and 5-fluorou...

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Detalhes bibliográficos
Main Authors: Hagiwara, S, Kudo, M, Nakatani, T, Sakaguchi, Y, Nagashima, M, Fukuta, N, Kimura, M, Hayakawa, S, Munakata, H
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2007
Assuntos:
Translational Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2360253/
https://ncbi.nlm.nih.gov/pubmed/17971768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6604058
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